Background: Obesity can be caused by abnormalities of hypothalamic autophagy, which is closely regulated by the epigenetic modification of TSC1-mTOR. However, whether the weight-reducing effect of electroacupuncture may relate to the modification of TSC1-mTOR methylation and hypothalamic autophagy remain unclear. This study was conducted to reveal the possible mechanism by which …
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Background: Blood-brain barrier (BBB) disruption and gut microbiota dysbiosis play crucial roles in Alzheimer’s disease (AD). Lipopolysaccharide (LPS) stimulation triggered by gut microbial dysbiosis is an important factor in BBB disruption and systemic inflammation, but the mechanism of acupuncture regulation of BBB disruption via the gut microbiota in Alzheimer’s disease is not clear. …
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Objective: Acupuncture can improve the symptoms of alcohol-induced bodily injury and has been accepted by the World Health Organization. In this study, in vivo fluorescence imaging (IVFI) was applied to display and evaluate the effect of electroacupuncture on liver function in mice with chronic alcoholic liver injury. Methods: IVFI of the Cy5.5-galactosylated polylysine (Cy5.5-GP) …
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Objective: To investigate whether electroacupuncture at bilateral Tianshu (ST 25) and Zusanli (ST 36) acupoints could alleviate stress-induced irritable bowel syndrome (IBS) and evaluate its effect on gut microbiota and corticotropin-releasing factor (CRF). Methods: Thirty C57BL/6 mice were randomly divided into the normal, water avoidance stress (WAS), and WAS+EA groups (10 mice …
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Introduction and hypothesis: To examine the changes induced by electroacupuncture in stress urinary incontinence rats, including the urodynamics and collagen degradation-related cytokine molecular biological expression changes, and to explore the effect and mechanism of electroacupuncture treatment in stress urinary incontinence. Methods: Female SPF Sprague-Dawley rats were randomly assigned to five groups (n …
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Background: This review aims to systematically summarize and analyze recent high-quality animal research results about the use of acupuncture in Alzheimer’s disease patients. This information will be useful in providing a reference for future experimental research and an experimental basis for the clinical use of acupuncture in the treatment of Alzheimer’s …
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Purpose: Sepsis is the main cause of death in intensive care unit. Maladaptive cytokine storm and T-cell lymphopenia are critical prognosis predictors of sepsis. Electroacupuncture is expected to be an effective intervention to prevent sepsis. This study aims to determine the potential of electroacupuncture at ST36 (Zusanli) to prevent experimental septic …
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Moxibustion is a traditional Chinese medicine preparation, which has been clinically used to treat cardiac diseases in recent years. The present study aimed to examine the protective effects and possible mechanisms of moxibustion on doxorubicin-induced chronic heart failure in rats. The animals were divided into five groups, including the Control …
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Background: Da Huang Zhe Chong Wan improves the inhibitory immune status of mice with hepatocellular carcinoma by regulating Treg/Th1 balance. Hypothesis/purpose: To study the multi-material basis and multi-mechanisms of Da Huang Zhe Chong Wan against hepatocellular carcinoma by regulating Treg/Th1 balance in vitro and in vivo. Methods: UPLC-MS/MS was used to detect the …
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Purpose: Macrophage polarization contributes to the mechanisms of treating knee osteoarthritis. In previous studies, fire needling acupuncture has been shown to affect knee osteoarthritis favorably. However, the mechanism of fire needling acupuncture on macrophage polarization is not well-defined. Thus, this study was conducted to determine that fire needling acupuncture exerts a …
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