Background: Intestinal mucosal barrier dysfunction plays a crucial role in the pathogenesis of irritable bowel syndrome with diarrhea (IBS-D). In order to explore the mechanism of electroacupuncture (EA) treatment on intestinal mucosal barrier, this study observed the effect of electroacupuncture on aquaporins (AQPs), tight junctions (TJs), NF-κB pathway and the gut …
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Objective: To test the hypothesis that moxibustion may inhibit rheumatoid arthritis (RA) synovial inflammation by regulating the expression of macrophage migration inhibitory factor (MIF)/glucocorticoids (GCs). Methods: Fifty male Sprague-Dawley rats were randomly divided into five groups (n = 10 each): blank Control (CON) group, rheumatoid arthritis Model (RA) group, Moxibustion (MOX) group, MIF …
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Objectives: To observe the effect of Guasha on inflammation factors, apoptosis and autophagy in the cartilage tissue of knee joint in rats with knee osteoarthritis (KOA), so as to explore its mechanisms underlying improvement of KOA. Methods: A total of 51 male SD rats were randomized into three groups：blank control, knee osteoarthritis …
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Long noncoding RNA (lncRNAs) are involved in the pathogenesis of ulcerative colitis. Moxibustion, a traditional Chinese medicine, can improve symptoms in patients with ulcerative colitis and reduce intestinal inflammation in rats with ulcerative colitis. However, it remains unclear whether the ameliorative effect of moxibustion on intestinal mucosal inflammation in ulcerative …
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Severe acute pancreatitis (SAP) onset and development are closely associated with intestinal barrier injury. Evidence from clinical practice and research has shown that electroacupuncture (EA) at the Zusanli (ST36) acupoint can improve intestinal barrier function and abdominal symptoms in patients with severe acute pancreatitis; however, the specific mechanisms of action …
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Ginsenoside Rg1 (G-Rg1) has various pharmacological properties including antiobesity, immunomodulatory, and anti-inflammatory effects. This study aimed to explore the therapeutic effects and underlying mechanisms of G-Rg1 on colitis complicated by obesity. The results indicate that G-Rg1 effectively alleviates colitis in obese mice and improves serum lipid levels and liver function. …
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Numerous randomised controlled trials have suggested the positive effects of acupuncture on chronic obstructive pulmonary disease (COPD). However, the underlying therapeutic mechanisms of acupuncture for COPD have not been clearly summarized yet. Inflammation is central to the development of COPD. In this review, we elucidate the effects and underlying mechanisms …
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Acupuncture plays a vital anti-inflammatory action in sepsis by activating autonomic nerve anti-inflammatory pathways, such as sympathoadrenal medullary pathway, but the mechanism remains unclear. This study aims to explore the optimum parameter of electroacupuncture (EA) stimulation in regulating the sympathoadrenal medullary pathway and evaluate electroacupuncture‘s anti-inflammatory effect on sepsis. To …
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To investigate the molecular mechanism of Yi Wei Tang in preventing premature ovarian insufficiency-related osteoporosis from the hypothalamic perspective , and to screen for the key active and acting molecules in Yi Wei Tang. Cyclophosphamide was used to create the premature ovarian insufficiency rat model. Groups A, B, and C …
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Using a severe acute pancreatitis (SAP) rat model, the mechanism of electroacupuncture were studied on the intestinal function of pancreatitis. The SAP models were established by injecting 30% L-ornithine at hourly intervals, and were divided into two groups (14 in each): SAP model group, which was not treated, and electroacupuncture …
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