Research summary (Chinese Herbal Medicine): Efficacy and possible mechanism of Kai-xin-san in animal models of Alzheimer's disease: a systematic review and meta-analysis of preclinical - Frontiers in pharmacology, 2026.
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Alzheimer’s disease (AD) is a neurodegenerative disease with insidious onset and progressive development. It is clinically characterized by cognitive impairment, memory impairment and behavioral change. Chinese herbal medicine and acupuncture are important components of traditional Chinese medicine (TCM), and are commonly used in clinical treatment of Alzheimer’s disease. This paper …
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Background: Metabolic defects play a crucial role in Alzheimer’s disease (AD) development. Brown adipose tissue (BAT) has been identified as a novel potential therapeutic target for Alzheimer’s disease due to its unique role in energy metabolism. Electroacupuncture (EA) shows promise in improving cognitive ability and brain glucose metabolism in Alzheimer’s disease, …
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Background: Blood-brain barrier (BBB) disruption and gut microbiota dysbiosis play crucial roles in Alzheimer’s disease (AD). Lipopolysaccharide (LPS) stimulation triggered by gut microbial dysbiosis is an important factor in BBB disruption and systemic inflammation, but the mechanism of acupuncture regulation of BBB disruption via the gut microbiota in Alzheimer’s disease is not clear. …
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Background: Functional brain imaging changes have been proven as potential pathophysiological targets in early-stage Alzheimer’s Disease. Current longitudinal neuroimaging studies of Alzheimer’s Disease treated by acupuncture, which is one of the growingly acknowledged non-pharmacological interventions, have neither adopted comprehensive acupuncture protocols, nor explored the changes after a complete treatment duration. Thus, …
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Background: This review aims to systematically summarize and analyze recent high-quality animal research results about the use of acupuncture in Alzheimer’s disease patients. This information will be useful in providing a reference for future experimental research and an experimental basis for the clinical use of acupuncture in the treatment of Alzheimer’s …
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Background: Alzheimer’s disease is a progressive neurodegenerative disease. Numerous cases have illustrated that the acupuncture method could improve Alzheimer’s disease patients’ cognitive function and daily living ability. However, the optimal acupuncture treatments remain controversial. Therefore, we aimed to conduct a systematic review to compare the efficacy of multiple acupuncture therapies for …
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Objectives: To study whether moxibustion can improve the learning and memory ability of APP/PS1 mice by reducing the pathological products Aβ and Tau protein via decreasing N6-methyladenosine (m6A). Methods: APP/PS1 mice were randomly divided into model group (APP/PS1) and moxibustion group (APP/PS1+Mox). C57BL/6J mice were used as a control group (Control). Learning and …
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Objective: To determine acupuncture-related treatments’ effects and duration on improving cognitive function, physical function, and quality of life in patients with Alzheimer’s disease. Data sources: Eight electronic databases were searched for eligible randomized controlled trials from database inception to January 2021, including Medline, PubMed, EBSCO, Embase, Cochrane, Airiti Library, China National Knowledge …
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Objective: To systematically research the impact of warming needle moxibustion for Alzheimer’s Disease (AD). Methods: Four Chinese databases and six English databases were systematically searched. Randomized controlled trials (RCTs) involving the use of warming needle moxibustion to intervene in AD patients were included. Data were extracted from the included studies and methodological …
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