Alzheimer’s disease, as one of most common dementia, mainly affects older people from the worldwide. In this study, we intended to explore the possible mechanism of improving cognitive function and protecting the neuron effect by electroacupuncture. Method: We applied senescence-accelerated mouse prone 8 (SAMP8) mice as Alzheimer’s disease animal model, used …
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Methods: The active components and targets of Huang Qi Si Jun Zi Tang were searched in the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). The genes corresponding to the targets were retrieved using UniProt and GeneCard database. The herb-compound-target network and protein-protein interaction (PPI) network were constructed by …
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Background: Alzheimer’s disease is a neurodegenerative disease characterized by loss of recognition and memory. Neuroinflammation plays pivotal roles in the pathology of Alzheimer’s disease and affects the progression of the disease. Astrocyte and microglia, as main immune executors in the central nervous system (CNS), participate into the inflammatory response in Alzheimer’s …
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The present study aims to assess the neuroprotective effects of Qing yang shen, a Chinese herbal medicine, in Alzheimer’s disease cellular and animal models and to determine its underlying mechanisms involving ALP regulation. Methods: Qing yang shen extract was prepared and its chemical components were characterized by LC/MS. Then the pharmacokinetics …
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