Tag Archives: Animal Model

Xiao Yao Wan has been widely applied in China to treat stress-related illnesses, such as migraine, depression, Parkinson’s disease, insomnia, hypertension. In this study aims to explore the effect of Xiao Yao Wan on chronic unpredictable mild stress-induced depression and its underlying mechanisms. Chronic unpredictable mild stress-induced depression rat models were established, …

Alzheimer’s disease, as one of most common dementia, mainly affects older people from the worldwide. In this study, we intended to explore the possible mechanism of improving cognitive function and protecting the neuron effect by electroacupuncture. Method: We applied senescence-accelerated mouse prone 8 (SAMP8) mice as Alzheimer’s disease animal model, used …

Acupuncture has long been used to relieve some inner ear diseases such as deafness and tinnitus. The present study examined the effect of electroacupuncture on noise-induced hearing loss (NIHL) in animals. A NIHL rat model was established. Electroacupuncture pretreatment at 2 Hz or posttreatment at the right Zhongzhu (TE3) acupoint …

The Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome-driven inflammatory response plays a key role in the pathophysiology of depression. Mounting evidence suggests that acupuncture is an effective treatment for depression. In this study, we investigated the effects of acupuncture treatment at the acupoints Baihui (GV20) and Yintang (GV29) on …

Spinal cord injury is one of the serious central nervous system injuries and the incidence of spinal cord injury continues to increase. Previous studies have indicated that electroacupuncture is beneficial for promoting recovery after spinal cord injury. In the present study, we attempted to evaluate how electroacupuncture can promote the …

The present study aims to assess the neuroprotective effects of Qing yang shen, a Chinese herbal medicine, in Alzheimer’s disease cellular and animal models and to determine its underlying mechanisms involving ALP regulation. Methods: Qing yang shen extract was prepared and its chemical components were characterized by LC/MS. Then the pharmacokinetics …

This study explored the in vivo effects and mechanisms of the modern classical prescription Supplemented Gegen Qinlian Decoction Tang against diabetic kidney disease. Sixty rats were randomly divided into the normal group, model group, Gegen Qinlian Decoction Tang group, and rosiglitazone(ROS) group. The modified diabetic kidney disease rat model was …

We used an established preclinical social defeat stress mouse model to study whether EA treatment modulates PTSD-like symptoms and understand its underlying mechanisms. To this end, male C57BL/6 mice were subjected to repeated social defeat stress (RSDS) for 6 consecutive days to induce symptoms of PTSD and treated with EA …

team of researchers led by neuroscientists at Harvard Medical School has successfully used acupuncture to tame systemic inflammation in mice. In the study, published Aug. 12 in Neuron, acupuncture activated different signaling pathways that triggered either a pro-inflammatory or an anti-inflammatory response in animals with bacterially induced systemic inflammation. Further, the …

Sixty male C57BL/6J mice were randomly divided into 6 groups, namely normal control, sham operation, CRS model, medication, acupuncture plus smokeless moxibustion (Acu+smokeless Moxi) and acupuncture plus smoky moxibustion (Acu+smoky Moxi) groups, with 20 mice in each group. The CRS model was established by inserting a piece of polyporous sponge …