Ethnopharmacological relevance: Colorectal cancer is a common digestive tract malignant tumor that its morbidity and mortality seriously affect human health. At present, Da Cheng Qi Tang, a traditional Chinese medicine formula, has been clinically used as an adjuvant therapy for colorectal cancer. However, pharmacodynamic substance basis and therapeutic mechanism are still …
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Bupleurum chinense DC. (Chaihu) is a traditional Chinese medicine (TCM) used in the treatment of anxiety. But the anxiolytic mechanisms of bupleurum are still unclear. Therefore, this unknown is predicted by network pharmacology study with molecular docking in the present study. The components of bupleurum were obtained from the databases. …
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Background: Coronavirus disease 2019 (COVID-19) keeps spreading globally. Chinese medicine (CM) exerts a critical role for the prevention or therapy of COVID-19 in an integrative and holistic way. However, mining and development of early, efficient, multisite binding CMs that inhibit the cytokine storm are imminent. Methods: The formulae were extracted retrospectively from …
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Sjögren’s syndrome is an autoimmune disease, and its conventional treatment has exhibited limited therapeutic efficacy. Qing Zao Fang, a traditional Chinese medicine formula, is used in the treatment of Sjögren’s syndrome, but its chemical composition is complex, and its pharmacological mechanism is not clear. Therefore, this study aims to explore …
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Background: Da Huang Zhe Chong San improves the inhibitory immune status of mice with hepatocellular carcinoma by regulating Treg/Th1 balance. Hypothesis/purpose: To study the multi-material basis and multi-mechanisms of Da Huang Zhe Chong San against hepatocellular carcinoma by regulating Treg/Th1 balance in vitro and in vivo. Methods: UPLC-MS/MS was used to detect the …
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Benefiting from the development of network pharmacology, Traditional Chinese Medicine (TCM) shows great potential in modern drug discovery. Recently, more and more TCM-related databases have been established for both academic and industry research, but they are still insufficient in data standardization, integrity, and precision. To better accelerate the TCM research …
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Objective: This study aimed to determine the active ingredients of Huang Qi Si Jun Zi Tang and the targets in treating cancer-related fatigue so as to investigate the treatment mechanism of Huang Qi Si Jun Zi Tang for cancer-related fatigue. Methods: This study adopted the method of network pharmacology. The active ingredients …
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Formula Le Cao Shi, a traditional Chinese medicine (TCM), has been used as folk remedy for treating hepatitis B for a long time. In our previous study, the anti-hepatitis B effects of Le Cao Shi have been verified. In the present study, the anti-hepatitis B activities of Le Cao Shi …
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Context: Xin Bao San, a traditional Chinese herbal formula, is widely used in clinical treatment for cardiovascular diseases; however, the therapeutic effect of Xin Bao San on myocardial ischaemia-reperfusion injury (MI/RI) is unclear. Objective: This study evaluates the cardioprotective effect and molecular mechanism of Xin Bao San against myocardial ischaemia-reperfusion injury. Materials …
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Huang Qin Tang is a Traditional Chinese Medicine formula for ulcerative colitis. However, the pharmacology and molecular mechanism of Huang Qin Tang on ulcerative colitis is still unclear. Combined microarray analysis, network pharmacology, and molecular docking for revealing the therapeutic targets and molecular mechanism of Huang Qin Tang against ulcerative …
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