Background: Subthreshold depression is considered to be the precursor stage of major depression, which is correlated with functional impairment and increased suicide rate. Although there are multiple therapies for the treatment of subthreshold depression, the comparison and efficacy of various methods has yet to be evaluated. This study aimed to evaluate …
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Objectives: Xerostomia is a subjective sensation of dry mouth. It is commonly associated with salivary gland hypofunction. Both changes in the composition of the saliva and a reduction in the quantity secreted may be an objective finding of dry mouth. Although there are no currently available cures for the conditions resulting …
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Background: Menstrual migraine without aura refers to a specific type of migraine that is associated with the female ovarian cycle. It is particularly serious and has brought huge life pressure and mental burden to female patients. Acupuncture has been commonly used to prevent migraines and relieve concomitant emotional disorders; however, the …
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This study is aimed at exploring the possible mechanism of action of the Suan Zao Ren decoction in the treatment of Parkinson’s disease with sleep disorder based on network pharmacology and molecular docking. Traditional Chinese Medicine Systems Pharmacology (TCMSP) was used to screen the bioactive components and targets of SZRD, …
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Ethnopharmacological relevance: Corn silk is composed of the style and stigma of Zea maysL. Its medical value was first reported in “Southern Yunnan Materia Medica” in the Ming Dynasty. It was considered to be a heat-clearing and diuretic drug. In “Zhejiang Folk Herbal Medicine,” the following has been reported: “Corn silk …
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Objective: To explore the molecular mechanism mediating the inhibitory effect of Chuanxiong Rhizoma against brain metastasis of lung cancer using network pharmacology methods and molecular docking. Methods: The chemical components of Chuanxiong Rhizoma and their targets were obtained through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. The relevant targets for brain metastasis of lung cancer …
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Background: : Since the outbreak of coronavirus disease (COVID-19), acupuncture has been widely used in the treatment of COVID-19. The research community has responded rapidly and have already been published many research articles about this topic. Methods: : We searched PubMed, Embase, Cochrane Library as well as CNKI, Wanfang and VIP from …
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Background: To systematically appraise and synthesize evidence, we conducted an overview of systematic reviews/meta-analyses (SRs/MAs) on acupuncture for stable angina pectoris. Methods: Eight databases were searched for SRs/MAs of acupuncture on stable angina pectoris. The methodological quality, reporting quality, and evidence quality were evaluated by Assessing the Methodological Quality of Systematic Reviews …
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Acupuncture and moxibustion have definite clinical effects on treating ulcerative colitis, but their mechanism is still unclear. To investigate the molecular mechanisms, we applied herb-partitioned moxibustion or electroacupuncture at the Tianshu (ST25) points on UC rats and used RNA sequencing to identify molecular consequences. Male Sprague Dawley (SD) rats were …
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Botanicals used in Traditional Chinese Medicine (TCM) are a rich source for drug discovery and provide models for multi-component drug development. To facilitate the studies of the actions of TCM drugs and expand their applications, a comprehensive database is urgently required. Methods: One online resource connects all the relevant data from …
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