Si Ni San (Frigid Extremities Powder)

Si Ni San (四逆散) spreads constrained Liver qi and harmonises the Liver and Spleen; for cold extremities caused not by yang deficiency but by qi constraint keeping the yang from reaching the limbs.

Sì Nì Sǎn  ·  四逆散  ·  Frigid Extremities Powder

English Name

Frigid Extremities Powder

Classical Source

Shang Han Lun, c. 220 CE

Ingredients

Actions & Functions

  • Spreads constrained Liver qi and releases constraint
  • Harmonises the Liver and Spleen

Indications

Liver qi constraint: cold fingers and toes (with a warm body), hypochondriac and epigastric distension, irritability, and possibly abdominal pain or diarrhoea.

Tongue & Pulse

Tongue: pale-red. Pulse: wiry.

Modifications

The base of Chai Hu Shu Gan San (add Xiang Fu, Chuan Xiong, Chen Pi) for stronger qi-moving.

Cautions & Contraindications

For cold limbs from constraint, not from true yang collapse (use Si Ni Tang for that).

About Attilio

Doctor of Chinese medicine, acupuncture expert and author of My Fertility Guide and My Pregnancy Guide.

Check Also

PubMed research

Network Meta-Analysis Finds Chinese Herbal Decoctions Improve Outcomes and Reduce Side Effects in Breast Cancer Treatment

Research summary (Traditional Chinese Medicine): Efficacy and safety of traditional Chinese medicine decoctions in breast cancer treatment: a network meta-analysis. - Frontiers in oncology, 2026.