Background: Cancer-related fatigue is the most common concomitant symptom in the treatment of colorectal cancer. Such patients often present with subjective fatigue state accompanied by cognitive dysfunction, which seriously affects the quality of life of patients.
Aim: To explore the effects of cognitive behavior therapy combined with Baduanjin exercise on cancer-related fatigue, cognitive impairment, and quality of life in patients with colorectal cancer after chemotherapy, and to provide a theoretical basis and practical reference for rehabilitation of colorectal cancer after chemotherapy.
Methods: Fifty-five patients with colorectal cancer after radical resection and chemotherapy were randomly divided into either an experimental or a control group. The experimental group received the intervention of cognitive behavior therapy combined with exercise intervention for 6 mo, and indicators were observed and measured at baseline, 3 mo, and 6 mo to evaluate the intervention effect.
Results: Compared with the baseline values, in the experimental group 3 mo after intervention, cognitive function, quality of life score, and P300 amplitude and latency changes were significantly better (P < 0.01). Compared with the control group, at 3 mo, the experimental group had significant differences in cancer-related fatigue, P300 amplitude, and quality of life score (P < 0.05), as well as significant differences in P300 latency and cognitive function (P < 0.01).
Compared with the control group, at 6 mo, cancer-related fatigue, P300 amplitude, P300 latency, cognitive function and quality of life score were further improved in the experimental group, with significant differences (P < 0.01). The total score of cancer-related fatigue and the scores of each dimension were negatively correlated with quality of life (P < 0.05), while the total score of cognitive impairment and the scores of each dimension were positively correlated with quality of life (P < 0.05).
Conclusion: Cognitive behavior therapy combined with body-building Baduanjin exercise can improve cancer-related fatigue and cognitive impairment in colorectal cancer patients after chemotherapy, and improve their quality of life.