Acupuncture reduces blood-brain barrier disorders and benefits Alzheimer’s disease

Background: Blood-brain barrier (BBB) disruption and gut microbiota dysbiosis play crucial roles in Alzheimer’s disease (AD). Lipopolysaccharide (LPS) stimulation triggered by gut microbial dysbiosis is an important factor in BBB disruption and systemic inflammation, but the mechanism of acupuncture regulation of BBB disruption via the gut microbiota in Alzheimer’s disease is not clear.

Objective: The current study evaluated the effect of manual acupuncture on blood-brain barrier dysfunction in APP/PS1 mice and examined the mechanism of gut microbiota by acupuncture in Alzheimer’s disease.

Methods: Acupoints were applied to Baihui (GV20), Yintang (GV29), and Zusanli (ST36) in the acupuncture group. Mice in the manual acupuncture plus antibiotics (MAa) group received antibiotics and acupuncture, while mice in the probiotics group received probiotics. Alterations in spatial learning and memory, the gut microbiota, tightly connected structure and permeability of blood-brain barrier, and the expression of LPS and inflammatory factors in each group were assessed.

Results: Compared to the normal (N) group, cognitive ability was significantly impaired, the gut microbiota composition was markedly altered, the blood-brain barrier was significantly disrupted, and the expression of LPS in serum and brain, serum TNF-α, and IL-1β were significantly increased in the Alzheimer’s disease group (p < 0.01). These changes were inhibited in the MA and probiotics groups (p < 0.01 or p < 0.05), and antibiotics reversed the benign regulatory effects of MA (p < 0.01 or p < 0.05).

Conclusion: Manual acupuncture benignly modulated the gut microbiota and blood-brain barrier dysfunction, reduced LPS, TNF-α, and IL-1β. These effects were comparable to probiotics. The decrease in LPS load and systemic inflammation may play important roles in the regulation of blood-brain barrier dysfunction by acupuncture, and the gut microbiota may be a potential target for the benign regulation of blood-brain barrier disruption by acupuncture.


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About Attilio

Doctor of Chinese medicine, acupuncture expert and author of My Fertility Guide and My Pregnancy Guide.

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