Acupuncture is effective for chronic spontaneous urticaria

Background: The effectiveness of acupuncture for patients with chronic spontaneous urticaria, reported in a few small-scale studies, is not convincing.

Objective: To investigate whether acupuncture leads to better effects on chronic spontaneous urticaria than sham acupuncture or waitlist control.

Design: A multicenter, randomized, sham-controlled trial. (Chinese Clinical Trial Registry: ChiCTR1900022994).

Setting: Three teaching hospitals in China from 27 May 2019 to 30 July 2022.

Participants: 330 participants diagnosed with chronic spontaneous urticaria.

Intervention: Participants were randomly assigned in a 1:1:1 ratio to receive acupuncture, sham acupuncture, or waitlist control over an 8-week study period (4 weeks for treatment and another 4 weeks for follow-up).

Measurements: The primary outcome was the mean change from baseline in the Weekly Urticaria Activity Score (UAS7) at week 4. Secondary outcomes included itch severity scores, self-rated improvement, and Dermatology Life Quality Index scores.

Results: The mean change in Weekly Urticaria Activity Score (range, 0 to 42) for acupuncture from baseline (mean score, 23.5 [95% CI, 21.8 to 25.2]) to week 4 (mean score, 15.3 [CI, 13.6 to 16.9]) was -8.2 (CI, -9.9 to -6.6). The mean changes in Weekly Urticaria Activity Score for sham acupuncture and waitlist control from baseline (mean scores, 21.9 [CI, 20.2 to 23.6] and 22.1 [CI, 20.4 to 23.8], respectively) to week 4 (mean scores, 17.8 [CI, 16.1 to 19.5] and 20.0 [CI, 18.3 to 21.6], respectively) were -4.1 (CI, -5.8 to -2.4) and -2.2 (CI, -3.8 to -0.5), respectively.

The mean differences between acupuncture and sham acupuncture and waitlist control were -4.1 (CI, -6.5 to -1.8) and -6.1 (CI, -8.4 to -3.7), respectively, which did not meet the threshold for minimal clinically important difference. Fifteen participants (13.6%) in the acupuncture group and none in the other groups reported adverse events. Adverse events were mild or transient.

Limitation: Lack of complete blinding, self-reported outcomes, limited generalizability because antihistamine use was disallowed, and short follow-up period.

Conclusion: Compared with sham acupuncture and waitlist control, acupuncture produced a greater improvement in Weekly Urticaria Activity Score, although the difference from control was not clinically significant. Increased adverse events were mild or transient.

Reference: https://pubmed.ncbi.nlm.nih.gov/37956431/

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About Attilio

Doctor of Chinese medicine, acupuncture expert and author of My Fertility Guide and My Pregnancy Guide.

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