Chinese Herbal Medicine

Codonopsis radix is an important edible and medicinal plant resource for immunomodulation in China and Southeast Asia. However, the chemical quality evaluation of Codonopsis radix in Chinese Pharmacopoeia is still lacking; therefore, it is necessary to develop an effective method to evaluate its quality accurately and systematically. Herein, a reliable …

Yi Fei Jie Du Tang is a traditional Chinese medicine formulation. Our previous studies have demonstrated that YFJDT can be used to treat non-small-cell lung cancer (NSCLC), but its protective effect against NSCLC and its mechanisms remain unclear. In the present study, we evaluated the protective effects and potential mechanisms …

Background: Since the outbreak of coronavirus disease 2019 (COVID-19) in late 2019, it has evolved into a global pandemic that has become a substantial public health concern. COVID-19 is still causing a large number of deaths in several countries around the world because of the lack of effective treatment. Aim: To systematically …

Coronavirus disease (COVID-19) is a new infectious disease associated with high mortality, and traditional Chinese medicine decoctions have been widely used for the treatment of patients with COVID-19 in China; however, the impact of these decoctions on severe and critical COVID-19-related mortality has not been evaluated. Therefore, we aimed to …

Background: With the rising age of the global population, the incidence rate of cardiovascular and cerebrovascular diseases is increasing, which causes serious public health burden. The efforts for new therapeutic approaches are still being sought since the treatment effects of existing therapies are not quite satisfactory. Chinese traditional medicine proved to …

Background: The pathogenesis of depression remains largely unknown. Accumulating evidence demonstrates the existence of a complex relationship between gut microbiome composition and brain functions. Jia Wei Xiao Yao San is considered a potential antidepressant. However, the pharmacological mechanisms of Jia Wei Xiao Yao San have not yet been clarified. Purpose: This study …

Background and purpose: The occurrence of colorectal cancer is associated with a variety of factors. Accumulating evidence shows that peripheral differentiation of regulatory T cells (Tregs) is critical in controlling tumorigenesis. Our previous studies demonstrated that the Yi Yi Fu Zi Bai Jiang San extract exerted potent anticancer activities by significantly …

Depression is characterized by indifferent and slow thinking, leading to highly unfavorable social and economic burden. Hong Hua is a traditional Chinese medicine and has many pharmacological properties, such as anti-oxidative and anti-inflammatory activities. However, the underlying mechanism unraveling the effect of Hong Hua on depression is still unclear. Here, …

Background: Evidence has shown that the traditional Chinese herbal medicine Wu Mei Wan has a protective effect on ulcerative colitis. Here, we studied the anti-inflammatory effects and potential mechanisms of Wu Mei Wan on chronic colitis in mice. Methods: A dextran sulfate sodium (DSS)-induced chronic colitis model and CD45RBhighCD4+ T cell transfer …

Background: Chemotherapy has become the main means to prolong the life of patients with advanced digestive tract cancer; however, it is associated with serious toxicity and side effects. Compound Ku Shen Injection is a pure Chinese herbal preparation, which can assist chemotherapy, inhibit tumor cell proliferation, and reduce adverse reactions of …